Table 1. Worst severity suffered by patient, throughout all cycles for each stated toxicity.

		ECMF (n=979)		CMF (n=973)
Toxicity	Grade	N	%	N	%	P*
Nauseaa	0	134	13	244	25	<0.001
	1/2	697	71	657	67
	3	146	15	69	7
Vomiting	0	451	46	609	63	<0.001
	1/2	412	42	327	33
	3/4	113	11	36	3
Stomatitis	0	283	29	437	45	<0.001
	1/2	634	64	507	52
	3/4	61	6	27	3
Alopeciaa	0	87	9	234	24	<0.001
	1	72	7	472	48
	2	820	84	263	27
Constipation	0	516	53	674	69	<0.001
	1/2	390	40	271	28
	3/4	62	6	24	2
Infection	0	418	43	505	52	0.001
	1/2	465	47	397	41
	3/4	64	7	51	5
Fatiguea	0	131	13	154	16	0.03
	1/2	638	65	640	65
	3	204	21	177	18
Neutropenia	0	652	67	676	69	>0.99
	1/2	162	16	140	14
	3/4	151	15	143	15
Thrombocytopenia	0	916	93	907	93	>0.99
	1/2	54	6	55	6
	3/4	8	1	10	1
Diarrhoea	0	541	55	512	53	>0.99
	1/2	380	39	401	41
	3/4	56	6	58	6

^*P-values after Bonferroni correction from tests on full breakdown of toxicity grades.

^aCTC gradings for nausea and fatigue have a maximum of three and, for Alopecia, a maximum of two.