Table 2. Incidences of severea toxicity suffered by cycle and by patient.

	ECMF		CMF		Total
	N	%	N	%	N	%
Number of cycles	(n=7144)		(n=5298)		(n=12442)
Nausea	204	2.9	89	1.7	293	2
Vomiting	172	2.4	45	0.9	217	2
Stomatitis	86	1.2	34	0.6	120	1
Alopecia	3850	53.9	769	14.5	4619	37
Constipation	100	1.4	37	0.7	137	1
Infection	76	1.1	62	1.2	138	1
Fatigue	429	6.0	326	6.2	755	6
Neutropenia	275	3.9	227	4.3	502	4
Thrombocytopenia	10	0.1	11	0.2	21	1
Diarrhoea	78	1.1	87	1.6	165	1
Neutropenic Sepsisb	201	3	145	3	346	3
Number of patients c	(n=1004)		(n=1008)		(n=2012)
Nausea	169***	17	85	8	254	13
Vomiting	129***	13	48	5	177	9
Stomatitis	70**	7	33	3	103	5
Alopecia	821***	82	263	26	1084	54
Constipation	63***	6	26	3	89	4
Infection	208	21	163	16	371	18
Fatigue	212	21	183	18	395	20
Neutropenia	334	33	347	34	681	34
Thrombocytopenia	26	3	21	2	47	2
Diarrhoea	72	7	77	8	149	7

Asterisks indicate significantly higher number of patients, after Bonferroni correction (^*P<0.05, ^**P<0.01, ^***P<0.001).

^aSevere=reported CTC grade ⩾3 (⩾2 for alopecia).

^bNeutropenic Sepsis episodes inferred from incidences, of any grade, of neutropenia and infection reported in the same cycle.

^cGleaned from a reported severe grade or cause of treatment delay, reduction or hospitalisation.