Table 2.

Results of case-control analysis of C-318T, A49G and CT60 variants and JIA

Variant	Phenotype	N	Genotype1			Allele1		P2
			1/1	1/2	2/2	1	2
C-318T	Controls	350	80.9	17.7	1.4	89.7	10.3
C-318T	All JIA	650	83.8	15.4	0.8	91.5	8.5	0.20
C-318T	Persistent Oligoarticular	202	81.2	17.8	1.0	90.1	9.9	0.81
C-318T	Extended Oligoarticular	76	86.8	13.2	0.0	93.4	6.6	0.70
C-318T	Polyarticular	197	83.8	15.2	1.0	91.4	8.6	0.43
C-318T	Polyarticular RF+	50	86.0	14.0	0.0	93.0	7.0	0.39
C-318T	Systemic	90	84.4	14.4	1.1	91.7	8.3	0.52
C-318T	Other	35	88.6	11.4	0.0	94.3	5.7	0.31
A49G	Controls	345	36.2	49.6	14.2	61.0	39.0
A49G	All JIA	650	40.2	44.0	15.8	62.2	37.8	0.65
A49G	Persistent Oligoarticular	206	39.3	42.2	18.4	60.4	39.6	0.81
A49G	Extended Oligoarticular	78	34.6	48.7	16.7	59.0	41.0	0.70
A49G	Polyarticular	194	43.3	45.9	10.8	66.2	33.8	0.10
A49G	Polyarticular RF+	50	28.0	46.0	26.0	51.0	49.0	0.07
A49G	Systemic	88	45.5	36.4	18.2	63.6	36.4	0.58
A49G	Other	34	44.1	50.0	5.9	69.1	30.9	0.23
CT60	Controls	518	18.7	49.6	31.7	43.5	56.5
CT60	All JIA	818	19.3	46.8	33.9	42.7	57.3	0.68
CT60	Persistent Oligoarticular	257	14.4	50.2	35.4	39.5	60.5	0.13
CT60	Extended Oligoarticular	91	20.9	46.1	33.0	44.0	56.0	0.92
CT60	Polyarticular	221	21.3	44.8	33.9	43.7	56.3	0.96
CT60	Polyarticular RF+	68	11.8	50.0	38.2	36.8	63.2	0.13
CT60	Systemic	107	27.1	43.0	29.9	48.6	51.4	0.17
CT60	Enthesitis related	27	33.3	37.0	24.6	51.9	48.1	0.23
CT60	Other	47	19.2	48.9	31.9	43.6	56.4	0.98

¹For the C-318T SNP, allele 1 was -318C and allele 2 was -318T. For the A49G SNP, allele 1 was 49A, and allele 2 was 49G. For the CT60 SNP, allele 1 was A and allele 2 was G.

Allele and genotype percents are shown.

²P; Significance values for carriage of allele 2 are shown.