Table 3.
Odds ratios of SCCHN associated with CASP3 genotypes in the stratified analysis
| Stratified variables |
CASP3 (rs4647601:G>T) |
P‡ and trend test |
||||
|---|---|---|---|---|---|---|
| no. of case/control |
no. of case/control |
Adjusted OR (95% CI)† |
no. of case/control |
Adjusted OR (95% CI)† |
||
| GG | GT | GT vs. GG | TT | TT vs. GG | ||
| Age | ||||||
| ≤ 56 | 150/203 | 215/228 | 1.25 (0.93-1.67) | 93/82 | 1.62 (1.02-2.34) | 0.052/0.012 |
| >56 | 164/162 | 220/235 | 0.93 (0.69-1.56) | 88/83 | 1.05 (0.71-1.56) | 0.746/0.909 |
| Gender | ||||||
| Male | 245/281 | 331/364 | 1.04 (0.82-1.31) | 148/121 | 1.45 (1.07-1.97) | 0.062/0.032 |
| Female | 69/84 | 104/99 | 1.25 (0.80-1.98) | 33/44 | 0.94 (0.52-1.70) | 0.341/0.938 |
| Smoking status | ||||||
| Never | 83/192 | 116/213 | 1.27 (0.90-1.80) | 55/78 | 1.61 (1.04-2.48) | 0.077/0.028 |
| Former | 104/128 | 169/177 | 1.20 (0.86-1.68) | 69/57 | 1.54 (0.99-2.38) | 0.197/0.056 |
| Current | 127/45 | 150/73 | 0.76 (0.48-1.19) | 57/30 | 0.86 (0.48-1.54) | 0.261/0.461 |
| Alcohol use | ||||||
| Never | 76/165 | 118/205 | 1.21 (0.85-1.74) | 62/78 | 1.59 (0.95-1.85) | 0.044/0.038 |
| Former | 70/56 | 99/77 | 0.95 (0.59-1.54) | 37/24 | 1.13 (0.60-2.14) | 0.791/0.794 |
| Current | 168/144 | 218/181 | 1.07 (0.78-1.46) | 82/63 | 1.32 (0.86-2.00) | 0.864/0.228 |
| Tumor site | ||||||
| Oral cavity | 92/365 | 141/463 | 1.12 (0.82-1.53) | 49/165 | 1.15 (0.76-1.73) | 0.438/0.465 |
| Pharynx | 171/365 | 228/463 | 1.04 (0.81-1.33) | 99/165 | 1.28 (0.93-1.76) | 0.275/0.161 |
| Larynx | 51/365 | 66/463 | 0.96 (0.64-1.47) | 49/165 | 1.36 (0.81-2.30) | 0.266/0.330 |
The result is bolded if the 95% confidence interval does not include 1 or P < 0.05.
*
No. (cases/controls) for each stratum
†
Adjusted OR, odds ratios were adjusted for all covariates (age, gender, smoking status, and alcohol use), excluding the stratified variable.
‡
P value was from the χ2 test statistics from comparisons of genotype frequencies between cases and controls and P value for the allele trend test obtained from logistic regression analyses.