Table 4.
Frequencies of inferred haplotypes and diplotypes of CASP3 based on the observed genotypes in SCCHN cases and cancer-free control
| Cases | Controls | Crude OR | Adjusted OR* | |||
|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | |||
| Haplotypes | N=1860 | N=1986 | ||||
| GCG | 705 | (37.9) | 814 | (41.0) | 1.00 | 1.00 |
| TCG | 759 | (40.8) | 745 | (37.5) | 1.18 (1.02, 1.36) | 1.18 (1.02-1.37) |
| GCA | 229 | (12.3) | 215 | (10.9) | 1.25 (1.01, 1.56) | 1.21 (0.96-1.51) |
| MAF<0.1 | 167 | (8.97) | 211 | (10.6) | 0.89 (0.70, 1.11) | 0.92 (0.72-1.17) |
| P value | 0.024† | 0.017‡ | 0.050§ | |||
| Diplotype∥ | N=930 | N=993 | ||||
| 0 | 227 | (24.4) | 277 | (27.9) | 1.00 | 1.00 |
| 1 | 398 | (42.8) | 448 | (45.1) | 1.08 (0.87-1.35) | 1.06 (0.84-1.34) |
| 2 | 305 | (32.8) | 268 | (27.0) | 1.39 (1.09-1.77) | 1.36 (1.06-1.75) |
| 0 or 1 | 625 | (67.2) | 725 | (73.0) | 1.00 | 1.00 |
| 2 | 305 | (32.8) | 268 | (27.0) | 1.32 (1.09-1.61) | 1.31 (1.07-1.61) |
*
Adjusted for sex, age, smoking status and alcohol use in a logistic regression model.
†
Pearson’s χ2-test were used to test for the difference in the distribution of all haplotypes/diplotypes between cases and controls.
‡
Likelihood ratio test for the significance of haplotypes associated with SCCHN risk.
§
Likelihood ratio test for haplotypes effect with adjustment for sex, age, smoking status and alcohol use.
∥
Diplotype was coded as 0 if there was no TCG or GCA in the haplotype pair; 1 if there was only one copy of TCG or GCA in the haplotype pair; and 2 if there were 2 copies of TCG or GCA in the haplotype pair.