Table 1.
Lipids and Proteins Targeted to Lipid Rafts and Caveolae
| Lipid Rafts | Caveolae | Ref. |
|---|---|---|
| Lipid components: | Lipid components: | [90, 115, 209, 210, 211, 212] |
| Cholesterol | Cholesterol | |
| Sphingomyelin | Sphingomyelin | |
| Glyco-sphingolipid | Glyco-sphingolipid | |
| Phosphatidylinositol 4,5-bisphosphate | Phosphatidylinositol 4,5-bisphosphate | |
| Ganglioside GM1 | Ganglioside GM1 | |
| Ganglioside GM3 | ||
| Structural proteins: | Signalling proteins: | |
| Flotillin-1 and –2 | Flotillin-1 and –2 | [9, 10, 11, 24, 213] |
| Caveolin-1, -2 and –3 | ||
| Structural proteins: Flotillin-1 and -2 | Signalling proteins: | |
| H-Ras | H-Ras | [32, 42, 48, 49, 56, 57, 115, 160, 214] |
| Gi, Go, Gβ | Gq | |
| Src kinases | Src kinases | |
| Syk kinase | eNOS | |
| Grb2, Erk2 | Phosphatidylinositol 3-kinase | |
| Shc | Phospholipase C | |
| Receptors: | Receptors: | |
| PDGF receptor | PDGF receptor | [56, 96, 115, 128, 136, 137, 215] |
| EGF receptor | EGF receptor | |
| IGF-1 receptor | IGF-1 receptor | |
| TrkA, TrkB | TrkA | |
| CD36 | ||
| GPI-Anchored proteins: | ||
| e.g. CD59 | uPAR | [216, 217] |
EGF: epidermal growth factor; eNOS: endothelial nitric oxide synthase; Erk: extracellular signal-regulated kinase; IGF: insulin-like growth factor; PDGF: platelet-derived growth factor; Trk: tyrosine kinase receptor; uPAR: urokinase-type plasminogen activator receptor.