Table 5.
Site-selective photoaffinity labeling data for CCK receptors.
| CCK1 receptor | |||
|---|---|---|---|
| Photolabile probe | Domain | Residue | Reference |
| Bpa24 CCK | ECL 3 | Glu345* | (Ding et al., 2001) |
| pNO2-Phe27 CCK | ECL 2 | Arg197 | (Arlander et al., 2004) |
| Bpa29 CCK | ECL 3 | His347* | (Hadac et al., 1998) |
| pNO2-Phe33 and BPA33 CCK | N terminus | Trp39 | (Ji et al., 1997; Hadac et al., 1999) |
| CCK2 receptor | |||
| Photolabile probe | Domain | Residue | Reference |
| Bpa24 CCK | ECL 1 | Phe122 | (Dong et al., 2005) |
| Bpa33 CCK | ECL 1 | Thr119 | (Dong et al., 2005) |
Numbering of CCK probes based on CCK-33; Bpa, p-benzoyl-L-phenylalanine; pNO2-Phe, p-nitro-phenylalanine; ECL, extracellular loop.
*
Glu345 and His347 identified in rat CCK1 receptor correspond to Glu344 and Arg346, respectively, in the human CCK1 receptor sequence.