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. 2008 Nov;10(11):1213–1221. doi: 10.1593/neo.08652

Figure 3.

Figure 3

Down-regulation of Nf1 and Nf2 occurs at the posttranscriptional level. (A) Protein lysates of WT Schwann cells and six different TEC3KO schwannomas were analyzed for Nf1 and Nf2 proteins. Note the marked down-regulation of both proteins in comparison to the actin control. (B) Real-time PCR analysis of mRNA for Prkar1a, Nf1, and Nf2 from WT Schwann cells and TEC3KO tumors. Results are shown as averaged expression among all six tumors compared with WT Schwann cells. ΔΔCt was calculated compared with a Gadph standard, and error bars represent the relative SD.