Table 3.
Clonality by PCR for IGH by Diagnosis
| Positive cases detected by specific primer sets [n (% cases studied)] |
|||||||
|---|---|---|---|---|---|---|---|
| Diagnosis | Cases studied (n) | Positive cases [n (%)] | FR1 | FR2 | FR3 | DH1-6 | DH7 |
| ALK+ ALCL | 28 | 3 (11) | 0 (0) | 1 (4) | 1 (4) | 2 (7) | 1 (4) |
| ALK− ALCL | 35 | 3 (9) | 1 (3) | 1 (3) | 2 (6) | 1 (3) | 0 (0) |
| SPTCL, HSTCL, T-LGL, and ETCL | 11 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Total PTCL | 74 | 6 (8) | 1 (1) | 2 (3) | 3 (4) | 3 (4) | 1 (1) |
| Pre-B-ALL | 24 | 23 (96) | 17 (71) | 23 (96) | 19 (79) | 6 (25) | 1 (4) |
FR primer sets amplified complete rearrangements inIGH between variable segment (VH), diversity segment (DH), and joining segment (JH). DH primer sets amplified incomplete rearrangements between DH and JH. ETCL, Enteropathy-type T-cell lymphoma; HSTCL, hepatosplenic T-cell lymphoma; SPTCL, subcutaneous panniculitis-like T-cell lymphoma.