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. 2008 Sep 24;8:261. doi: 10.1186/1471-2148-8-261

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Copyright ©2008 Fetterman et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Residues experiencing neutral changes and positive selection in the forkhead domain. The forkhead domain of FOXA3 is shown bound to DNA. Residues with neutral changes identified in the FoxA (blue), FoxD (red) and FoxP (yellow) clusters and residues under positive selection identified in the Protostomia lineage of the FoxA cluster (orange) are highlighted and indicated with arrows. Alpha helices 1, 2 and 3, beta sheets 1 and 2, and wings 1 and 2 are denoted H1, H2, H3, B1, B2, W1 and W2 respectively.