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Effects of GABA (100 μm) and bicuculline (BIC; 30 μm) on the single-unit activities of rat SCN neurons. A–H, Firing rate histograms from eight different neurons. In A, C, and E, both GABA and bicuculline altered the unit activities, whereas in B, D, and F, GABA, but not bicuculline, had effects on neuronal firing. G, H, Blockade by bicuculline of monophasic (G) and biphasic (H) excitatory responses to GABA.
