Fig. 1.

Representative histology from P102L patients showing appearances graded semi-quantitatively. (A, C and E) show progressively worsening degrees of spongiform change on haematoxylin and eosin stain of brain slices. (B, D and F) show increasing levels of plaque deposition, as demonstrated by immunohistochemistry with anti-PrP antibody ICSM 35. Views in the left-hand column do not necessarily correspond to the same region as the right column. A, C and D are from Patient 2.VII.2. B and E are from Patient VII.4, while panel F is from Patient 3.VIII.1. The scaling bar shown is 100 µM.