Fig. 3.

Pedigree of the original ‘W’ kindred (in grey) with newly identified and linked kindreds (in black). Only presumed affected patients (filled symbols) or those thought to have transmitted the mutation but not known to be affected (empty symbols) have been included for the sake of simplicity and confidentiality. All of the new patients have been linked genealogically to the original family with the exception of the two small pedigrees on the right of the diagram where possible links are represented with a question mark. Members of these kindreds both share a microsatellite background with the ‘W’ kindred and have ancestors closely located geographically to them. Possible reasons for the inability to uncover an exact link genealogically are discussed in the text.