Figure 7.

Model for the Coordination of the Inner and Outer Envelope Division Machineries.

ARC6 positioning is probably determined by Z ring position. ARC6 functions in part to regulate FtsZ filament formation. The C-terminal IMS region of ARC6 interacts directly with the C-terminal IMS region of PDV2 and positions PDV2 at the division site. PDV2, a dynamin recruitment protein, directs ARC5 localization and ring formation at the site of constriction in concert with PDV1. ARC6 may also position PDV1 at the division site, perhaps indirectly through an unknown factor (?). The connection between PDV2 and PDV1 is unclear (?) at this time.