Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Biomaterials. 2008 Aug 28;29(33):4429–4438. doi: 10.1016/j.biomaterials.2008.08.004

Table 2.

Apparent permeability (P_app) and uptake of drug in MDCK-MDR1 and MDCK-wt cells.

Cell Type	P_app (cm/sec) × 10⁻⁵			Uptake^a(μg/mg protein)
Cell Type	Drug in Solution	Unconjugated NPs	TAT- conjugated NPs	Drug in Solution	Unconjugated NPs	TAT- conjugated NPs
MDCK- MDR1	0.05	1.97	2.4	0.04 ± 0.01	0.59 ± 0.14	3.63 ± 0.75
MDCK-wt	0.60	0.81	3.0	0.29 ± 0.05	0.53 ± 0.02	0.83 ± 0.09

P_app was calculated from the transport studies (n=6; see transport figures in supporting information).

^a

Data are mean ± s.e.m (n = 6).

^*

p < 0.05 for the TAT-conjugated group between MDCK-MDR1 and MDCK-wt cells.