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. 2008 Oct 24;283(43):29156–29165. doi: 10.1074/jbc.M802365200

FIGURE 1.

FIGURE 1.

Rat eyes with high IOP and normalized IOP progress toward glaucomatous RGC loss. A, mean IOP values ± S.D., n = 4–6 eyes/group. At day 0 eyes were surgically cauterized or were left normal. At days 3 or 10 post-cautery the indicated groups were treated with β-blocker (betaxolol 0.5%, Alcon Labs), the other groups were untreated. Daily treatment with β-blocker continued until day 28. Within 3 days of β-blocker treatment, cauterized eyes experienced a significant reduction of high IOP and their IOPs were not different from non-cauterized eyes as long as betaxolol was applied. B, progressive loss of RGCs triggered by short-term ocular hypertension. Mean RGC loss ± S.E., n = 6 retinas/group/experiment, from 3 independent experiments. Normalization of IOP with betaxolol (from day ∼7 onwards) reduces the rate of RGC loss, but does not prevent it. When betaxolol was used successful normalization of IOP were verified, but is not shown here for clarity. Normal non-cauterized eyes were obtained from 3 rats. In the test groups 6 rats for each time point had both eyes cauterized to elevate pressure, and one eye was treated with betaxolol to lower pressure. *, significant RGC loss compared versus normal non-cauterized retinas (p ≤ 0.01). **, significantly higher RGC loss in cauterized eyes compared versus cauterized eyes treated with betaxolol (p ≤ 0.01).