FIGURE 1.
Top, schematic representation of the full-length C-terminal and the CT segments tested for complex formation with CaM. Residue numbers refer to the rabbit isoforms of CaV1.2 (top number) and CaV1.1 (bottom number). The EF-hand (4), A and C (12, 17), and IQ (15) motifs have been implicated as important for calcium-dependent inactivation and/or CaM binding. Bottom, alignment of CaV1.2 residues 1637–1673 and CaV1.1 residues 1512–1548 (numbering according to rabbit sequences). Arrows and bold-face indicate residues that were subjected to mutational exchange between the two isoforms. The species and accession numbers for the illustrated sequences are indicated. The sequence for chicken CaV1.2 and dog CaV1.1/1.2 are predicted (p) only.