FIGURE 1.

Partial inhibition of thrombin-induced NO production by eNOS knock-out. Equal numbers of washed mouse platelets (10⁹/ml) isolated from wild-type C57 black mice (WT) or eNOS knock-out (eNOS^–/–) mice were stimulated with 0.1 unit/ml thrombin. NO release was measured in real time with a porphyrinic microsensor. Shown are representative traces (A) and quantitative data from four experiments (B).