FIGURE 4.

Stimulatory role of iNOS in mouse platelet aggregation and secretion. Representative aggregation and secretion traces of washed wild-type (WT) or iNOS^–/– mouse platelets stimulated with 0.02 unit/ml thrombin (A), 0.5 μg/ml collagen (B), 0.05 unit/ml thrombin (C), or 5 μg/ml collagen (D). The statistical difference between WT and iNOS^–/– platelets was analyzed using a paired t test with following results: A, aggregation p = 0.0053, n = 5; secretion p = 0.0086, n = 5; B, aggregation p = 0.0106, n = 6; secretion p = 0.0052, n = 4.