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. 2008 Oct 24;283(43):29572–29585. doi: 10.1074/jbc.M801547200

FIGURE 6.

FIGURE 6.

Role of PKG in sildenafil (SIL)-induced expression of Bcl-2 and Bax. A, isolated mouse hearts infused with sildenafil (1 μm) for 10 min in the absence or presence of KT5823 (1 mg/kg). B, mouse cardiomyocytes treated with sildenafil (1 μm) in the absence or presence of KT5823 (2 μm) for 1 h. C, densitometry analysis of the Bcl-2/actin ratio (* indicates p < 0.05 versus control and KT + sildenafil; n = 3); D, Bax/actin ratio (n = 3; NS); E, Bcl-2/Bax ratio (* indicates p < 0.05 versus control and KT + sildenafil; ** indicates p < 0.01 versus control and KT + sildenafil; n = 3).