Fig. 1.

Short-term AAT treatment of DIA NOD mice restores euglycemia. Spontaneous DIA NOD mice (NOD-sp) were treated with insulin alone or treated with a short term of AAT plus insulin therapy. In the insulin control group all animals stayed diabetic (150/150). In contrast 14 of 16 mice treated with AAT and insulin became and remained normoglycemic. AAT-treated animals were compared with insulin control mice by using Wilcoxon signed ranked test (P < 0.0001).