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. 2008 Oct 13;105(42):16356–16361. doi: 10.1073/pnas.0808699105

Fig. 3.

Fig. 3.

Nicotine-induced reduction of DNMT1 mRNA is expressed at a higher level in laser-microdissected layer I FC than in the whole FC samples. Mice were treated with nicotine (22 μmol/kg s.c. four times a day for 4 days) and were killed 2 h after the last injection. DNMT1 mRNA values in vehicle treated mice are as follows: whole FC, 3.2 fmol DNMT1 mRNA/0.1 pmol NSE mRNA; layer I, 18 fmol DNMT1 mRNA/0.1 pmol NSE mRNA. Each value is the mean ± SE of five mice. *, P < 0.01; **, P < 0.001, Student's t test between vehicle and nicotine treatment.