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Reduced ex vivo class-switch recombination in PCNA−/−tgK164R mice. Relative switching to IgG3 and to IgG1 in a total of eight wild-type and eight transgenic mice from six different experiments. The efficiency of switching in the wild-type group within each experiment was defined as 100% and two replicates were assayed for each stimulation. The data shown represent relative mean efficiency of switching ± SEM. P-values were calculated using two-tailed unpaired Student's t tests.
