Table 1.

Binding and signaling properties of PTH analogs

	Binding				cAMP			IP3
	R0		RG		EC50 Log M	nM	Emax pmol/well (basal = 0.8 ± 0.1 pmol/well)	EC50 Log M	nM	Emax cpm/well (basal = 82 ± 41 cpm/well)
	IC50 Log M	nM	IC50 Log M	nM
PTH(1–34)	−7.37 ± 0.09	55	−9.37 ± 0.05	0.45	−9.74 ± 0.03	0.18	88 ± 1	−7.84 ± 0.07	14	772 ± 50
PTH(1–28)	−5.50 ± 0.14	3,900	−8.53 ± 0.06	3.0	−9.01 ± 0.03	0.99	94 ± 1	−7.44 ± 0.13	36	653 ± 53
M-PTH(1–34)	−8.70 ± 0.11	2.3	−9.16 ± 0.08	0.75	−9.06 ± 0.05	0.87	93 ± 2	−7.62 ± 0.08	24	600 ± 30
M-PTH(1–28)	−8.56 ± 0.09	3.0	−9.28 ± 0.07	0.56	−9.01 ± 0.05	0.97	94 ± 2	−7.39 ± 0.08	41	702 ± 44
M-PTH(1–21)	−7.07 ± 0.09	92	−9.34 ± 0.07	0.49	−8.93 ± 0.002	1.2	91 ± 1	−7.82 ± 0.07	15	820 ± 33
M-PTH(1–14)	−4.48 ± 0.05	34,000	−7.93 ± 0.04	12	−7.53 ± 0.05	30	88 ± 2	−7.28 ± 0.04	52	635 ± 16

Data (means ± SEM) are from five (binding) or three (IP₃ and cAMP) experiments, each performed in duplicate.