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. 2008 Oct 27;205(11):2465–2472. doi: 10.1084/jem.20080789

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© Péron et al.

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Figure 3. — In vivo and in vitro Ig-CSR deficiency in patients. (A) B cell phenotype. IgM and IgD expression was studied on CD19⁺CD27⁺ gated PBLs. Very few IgM⁺IgD⁺ cells were observed in P1, P2, and P3 (n = 1) compared with controls (n = 7). A reduction of IgA⁺ B cells on CD19⁺-gated PBLs was observed in P3 compared with an age-matched control (n = 2). (B) Defective IgE and IgA production by CSR activated patients' PBLs. PBLs were activated by sCD40L plus IL-4 for 12 d or sCD40L plus IL-10 for 10 d for CSR toward IgE (P1, n = 2; P2 and P3, n = 1; controls, n = 10) and IgA (P1 and P3, n = 1; controls, n = 5), respectively. Proliferation was assessed after a 5-d stimulation with sCD40L plus IL-4 by measuring [³H]thymidine incorporation. Error bars represent one SD (P1 and P3, n = 1; controls, n = 10).