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BKCa Channel Ca2+ Binding Parameters
| Binding Site | Membrane Potential (mV) |
KC (μM) | KO (μM) | M | f | C |
|---|---|---|---|---|---|---|
| Ca2+ Bowl | ||||||
| ΔEΔR | −80 | 3.1 ± 0.2 | 0.88 ± 0.06 | 3.55 | ||
| ΔEΔR | 0 | 3.1 | 0.88 | 3.55 | ||
| RCK1 | ||||||
| ΔEΔB(D2A2) | −80 | 23.2 ± 2.6 | 4.9 ± 0.6 | 4.75 | ||
| ΔEΔB(D5N5) | −80 | 26.8 ± 3.8 | 5.6 ± 0.8 | 4.75 | ||
| ΔEΔB(D2A2) + Cooperativity | −80 | 13.7 ± 2.3 | 2.8 ± 0.5 | 0.45 ± 0.1 | ||
| ΔEΔB(D5N5)+ Cooperativity | −80 | 9.4 ± 1.8 | 1.8 ± 0.2 | 0.27 ± 0.05 | ||
| ΔEΔB(D2A2) | 0 | 15.8 ± 3.1 | 2.10 ± 0.4 | 1.8 × 107 | 7.52 |
