Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Nov;132(5):507–520. doi: 10.1085/jgp.200810083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Wynia-Smith et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — Homology modeling of native V659 side chain orientation in closed and open states. (A) View from the cytoplasm of the open state homology model, illustrating V659 at the intersection of adjacent S6 domains and near the bundle crossing. The native V659 side chain is represented as red space–filled spheres, whereas the backbone α-helix is represented as either light blue or tan ribbon. For clarity, the S1–S4 domains are not shown. (B) View from the cytoplasm of the closed state homology model, with the V659 side chain near S6 domain and the S4-S5 linker. (C) Close-up view of the pocket surrounding the V659 side chain in the open state, tilted forward relative to views in A and B ∼45° about the S4-S5 linker. (D) Close-up view of the pocket surrounding the V659 side chain in the closed state.