TABLE I.

Deactivation Values at −100 mV

Channel	τfast (ms)	τslow (ms)	τaverage (ms)	n
Ctrl	64.3 ± 3.1	254.7 ± 10.3	123.9 ± 6.1	9
S654C	84.4 ± 5.2a	486.5 ± 38.9b	285.5 ± 41.4b	6
I655C	139.4 ± 4.9b	734.5 ± 22.8b	504.8 ± 21.8b	10
F656C	71.8 ± 14.1	259.4 ± 60.1	107.2 ± 7.1	3
G657C	14.8 ± 1.3b	104.5 ± 12.9b	40.5 ± 4.3b	6
N658C	5.5 ± 0.03b	51.1 ± 2.9a	11.7 ± 1.5b	5
V659C	113.6 ± 6.4b	1,084.9 ± 40.7b	798.6 ± 62.9b	5
S660C	49.3 ± 3.6a	142.7 ± 8.7b	107.9 ± 2.5b	3
A661C	91.1 ± 6.5a	321.9 ± 24.7b	188.1 ± 15.3b	6
I662C	92.9 ± 2.7a	506.2 ± 75.1b	400.4 ± 70.2b	6
I663C	112.3 ± 5.4b	394.9 ± 15.5b	258.9 ± 13.7b	9
Q664C	106.6 ± 8.2b	1,044.4 ± 67.2b	764.9 ± 69.2b	6
R665C	81.8 ± 16.8	319.7 ± 71.8b	147.3 ± 16.8	4
L666C	71.8 ± 13.1	147.2 ± 4.7b	99.4 ± 8.0a	6
Y667C	138.7 ± 7.7b	802.9 ± 56.5b	627.03 ± 67.6b	8
S668C	197.9 ± 25.5b	1,809.7 ± 118.2b	1,489.3 ± 85.6a	13

Values reported were obtained by double exponential fits to deactivating current traces (see Materials and methods). Values are ± SEM.

^aP < 0.05.

^bP < 0.001.