TABLE I.

Summary of Kinetic Parameters for QA Block of TRPV1^a

Blocker	Association rate constant kon(0 mV), (M−1s−1)	Dissociation rate constant koff (0 mV), (s−1)	zon (eo)	zoff (eo)
TEA (n = 3)	1.04 × 106 ± 4.8 × 105	2.89 × 104 ± 3.2 × 103	0.94 ± 0.13	0.27 ± 0.03
TPrA (n = 3)	8.59 × 105 ± 1.5 × 105	1.23 × 104 ± 186	0.69 ± 0.14	−0.19 ± 0.01
TBA (n = 6)	2.5 × 105 ± 2.9 × 104	83.76 ± 10	0.93 ± 0.03	−0.63 ± 0.03
TPA (n = 5)	1.03 × 105 ± 4 × 104	10.73 ± 0.95	0.68 ± 0.06	−0.45 ± 0.02

The table summarizes the on- and off-rates for the four blockers used in this study and their associated valence.

^aData are mean ± SEM.