TABLE III.
UNIVARIATE AND MULTIVARIATE ANALYSIS OF PROGNOSTIC MARKERS ASSOCIATED WITH INTRAHEPATIC RECURRENCE-FREE SURVIVAL IN PATIENTS WITH LIVER TUMORS
| Variable | Hazard ratio | 95% CI | p Value |
|---|---|---|---|
| Univariate analysis | |||
| Age | 1.003 | 0.953–1.056 | 0.912 |
| Gender (male/female) | 1.508 | 0.938–2.782 | 0.095 |
| HBV (infected/non-infected) | 0.694 | 0.095–2.744 | 0.506 |
| HCV (infected/non-infected) | 1.654 | 0.739–5.589 | |
| Platelets count | 1.033 | 0.951–1.120 | 0.435 |
| Alanine aminotransferase | 0.998 | 0.987–1.008 | 0.761 |
| Total bilirubin | 1.129 | 0.360–3.107 | 0.826 |
| Prothrombin time | 1.003 | 0.974–1.033 | 0.840 |
| Indocyanine green | 0.999 | 0.960–1.034 | 0.958 |
| Alpha-fetoprotein | 1.000 | 0.999–1.000 | 0.588 |
| Tumor diameter (≤20 mm/>20 mm) | 1.274 | 0.878–1.913 | 0.207 |
| Tumor multiplicity (multiple/solitary) | 1.431 | 0.991–2.077 | 0.056 |
| Tumor stage | 1.810 | 1.021–3.257 | 0.042 |
| Tumor differentiation (moderate-poor/well) | 1.111 | 0.755–1.720 | 0.607 |
| Liver cirrhosis (cirrhosis/no cirrhosis) | 0.765 | 0.529–1.109 | 0.154 |
| TJ-48 (treated/not treated) | 0.545 | 0.292–0.889 | 0.013 |
| Multivariate analysis | |||
| Gender | 1.187 | 0.699–2.263 | 0.546 |
| Tumor multiplicity | 1.742 | 0.967–3.164 | 0.064 |
| Tumor stage | 0.936 | 0.408–2.244 | 0.878 |
| Liver cirrhosis | 0.784 | 0.523–1.176 | 0.236 |
| TJ-48 treatment | 0.512 | 0.261–0.890 | 0.016 |
The results from Cox proportional hazard analysis are shown for all clinical variables available in this study. For multivariate analysis, only those variables that have a p-value less than 0.2 in the univariate analysis were selected.