TABLE IV.
EFFECT OF TJ-48 ON DEVELOPMENT OF MOUSE LIVER TUMORS, AND 8-OHDG- AND PCNA- POSITIVE HEPATOCYTES
| Strain | Group | Weeks | Tumor development (%) | 8-OHdG-positive hepatocytes (%) | PCNA-positive hepatocytes (%) |
|---|---|---|---|---|---|
| C57BL/6N | Control (N = 5) | 10 | 0 (0/5) | 28.7 ± 5.9 | 36.5 ± 5.6 |
| DEN (N = 5) | 0 (0/5) | 53.4 ± 1.51 | 55.6 ± 2.71 | ||
| DEN + TJ-48 (N = 5) | 0 (0/5) | 40.2 ± 2.42 | 55.2 ± 4.41 | ||
| Control (N = 5) | 22 | 0 (0/5) | 26.0 ± 5.7 | N/D | |
| DEN (N = 27) | 22.23 (6/27) | 67.0 ± 2.11 | N/D | ||
| DEN + TJ-48 (N = 20) | 0 (0/20) | 24.9 ± 3.52 | N/D | ||
| C3H/HeN | Control (N = 5) | 10 | 0 (0/5) | 31.8 ± 1.2 | 25.3 ± 3.1 |
| DEN (N = 5) | 0 (0/5) | 59.2 ± 2.31 | 42.0 ± 3.01 | ||
| DEN + TJ-48 (N = 5) | 0 (0/5) | 36.1 ± 3.72 | 40.9 ± 3.31 | ||
| Control (N = 5) | 22 | 0 (0/5) | 25.8 ± 4.3 | N/D | |
| DEN (N = 19) | 63.2 (12/19) | 37.1 ± 2.6 | N/D | ||
| DEN + TJ-48 (N = 17) | 41.2 (7/17) | 26.8 ± 5.0 | N/D |
Data are expressed as mean ± SEM. N/D, not determined.
1
p < 0.05, compared to control group at the corresponding time point (one-way ANOVA with Newman-Keul’s post-hoc test).
2
p < 0.05, compared to DEN group at the corresponding time point (one-way ANOVA with Newman-Keul’s post-hoc test).
3
p < 0.05, compared to DEN + TJ-48 group at the corresponding time point (Yates 2×2 Chi square test).