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. 2008 Oct 31;3(10):e3601. doi: 10.1371/journal.pone.0003601

Figure 6. Exogenous rh-HMGB1 triggers HIV-1 replication in iDC.

Figure 6

(a) iDC -infected with HIV-1BaL were cultured either alone or in the presence of aNK cells for 3 days. rh-HMGB1 (1 µg/ml) was added in some cultures. HIV replication was measured by p24 quantification in culture supernatant. (b) HIV-1-infected iDC were cultured either alone or in the presence of aNK cells for 3 days. Blocking anti-HMGB1 antibodies (10 µg/ml) or glycyrrhizin (10 µg/ml) were added at culture initiation. HIV replication was measured by p24 quantification in culture supernatant. The mean±sd of three independent experiments is shown. Statistical comparisons were made with the non-parametric Mann-Whitney test. * p<0.05.