Figure 5. Broadly neutralizing activity of cs- and fm-Abs.
A, sequence comparison of eight Abs identified from 80R-cs or -fm library selection. *Amino acid sequence in CDRL1 (161–164). ** 80R was identified from Tor2-S1 targeted library selection [17]; five fm-Abs were from both D480A or D480G and GD03 targeted library selection. B, Neutralization activity of the eight Abs (full-length IgG1) was tested with the same pseudotyped viruses as used in Fig. 3A at indicated Ab concentration. Cs5, cs84, fm6 and fm39 appeared to be the four BnAbs.