Table 3.
Linear regression models of serum cystatin C (mg/L) and creatinine (mg/dl) in US adolescents aged 12 to 19 yr, NHANES IIIa
| Dependent Variable | Covariate | Unadjusted Association β (95% CI) | Adjustedb for Demographics Model β (95% CI) | Fully Adjusted Modelc,d β (95% CI) |
|---|---|---|---|---|
| Cystatin C (mg/L) | Gendere | −0.092 (−0.122 to −0.063)g | −0.091 (−0.12 to −0.06)g | −0.039 (−0.061 to −0.016)g |
| Age (yr) | −0.009 (−0.015 to −0.003)g | −0.008 (−0.014 to −0.002)g | −0.015 (.−0.022 to −0.008)g | |
| Non-Hispanic blackf | −0.054 (−0.081 to −0.027)g | −0.049 (−0.075 to −0.022 )g | −0.045 (−0.070 to −0.021)g | |
| Mexican Americanf | −0.056 (−0.083 to −0.029)g | −0.050 (−0.075 to −0.025)g | −0.020 (−0.066 to −0.014)g | |
| Serum creatinine (mg/dL) | .203 (.127 to .279 )g | .160 (.077 to .25)g | ||
| Uric acid (mg/dL) | .040 (.025 to .054)g | .021 (.005 to .037)h | ||
| BUN (mg/dL) | .010 (.006 to .015)g | .004 (.001 to .008)h | ||
| Albumin (g/dL) | .030 (.019 to .082)g | |||
| Hemoglobin (g/dL) | .026 (.015 to .037)g | |||
| CRP (mg/dL) | .011 (−0.010 to .032) | |||
| TSH (μIU/mL) | .008 (.001 to .015)h | |||
| %BF | −0.350 (−0.500 to −0.190)g | |||
| FFM (kg) | .003 (.002 to −0.004)g | |||
| BMI (kg/m2) | −0.000 (−0.003 to .003) | |||
| R2 | N/A | .208 | .309 | |
| Creatinine (mg/dl) | Gendere | −0.100 (−0.140 to −0.068)g | −0.100 (−0.130 to −0.080)g | −0.030 (−0.067 to −0.002)h |
| Age (yr) | .029 (.021 to .037)g | .030 (.022 to .036)g | .030 (.021 to .036)g | |
| Non-Hispanic blackf | −0.039 (−0.077 to −0.002)h | .050 (.014 to .079)g | .070 (.042 to .100)g | |
| Mexican American f | −0.000 (−0.057 to .058) | −0.050 (−0.080 to −0.020)g | −0.040 (−0.068 to −0.006)h | |
| Serum cystatin C (mg/L) | .308 (.20 to .41)g | .190 (.09 to .30)g | ||
| Uric acid (mg/dL) | .053 (.041 to .065)g | .029 (.016 to .042)g | ||
| BUN (mg/dL) | .014 (.010 to .019)g | .008 (.004 to .010)g | ||
| Albumin (g/dL) | .083 (.030 to .140)g | |||
| Hemoglobin (g/dL) | .048 (.036 to .060)g | |||
| CRP (kg/m2) | .010 (−0.001 to .030) | |||
| TSH (μIU/mL) | .006 (−0.001 to .013) | |||
| %BF | −0.290 (−0.470 to −0.110)g | |||
| FFM (kg) | .007 (.005 to .009)g | |||
| BMI (kg/m2) | .003 (.0004 to .066)g | |||
| R2 | N/A | .350 | .462 |
a
CI, confidence interval; BUN, blood urea nitrogen; CRP, C-reactive protein; TSH, thyroid-stimulating hormone; %BF, percentage of body fat; FFM, free-fat mass; BMI, body mass index.
b
Adjusted for age, gender, and race/ethnicity.
c
Fully adjusted model for cystatin C: adjusted model + creatinine + uric acid + BUN.
d
Fully adjusted model for creatinine: adjusted model + cystatin C + BUN.
e
Male = reference population.
f
Non-Hispanic white = reference population.
g
P < .01.
h
P < .05.