Table 3.
Parameters of mineral metabolism in RTR and patients with chronic kidney diseasea
| Parameter | RTR
|
CKD
|
|||||
|---|---|---|---|---|---|---|---|
| TX | 3M | 12M | 3M versus 12M | CKD versus 3M | CKD versus 12M | ||
| Phosphate (mg/dl) | 5.0 ± 1.3 | 2.6 ± 0.6 | 3.0 ± 0.6 | 0.0005 | 3.3 ± 0.6 | <0.0001 | 0.01 |
| Hypophosphatemia (<2.3 mg/dl) (%) | 0 | 32 | 14 | 0.0004 | 4 | 0.0003 | 0.08 |
| Calcium (mg/dl) | 9.7 ± 0.8 | 10.0 ± 0.7 | 9.5 ± 0.6 | <0.0001 | 9.4 ± 0.3 | <0.0001 | 0.4 |
| Albumine (g/L) | 44.0 ± 4.7 | 43.4 ± 3.0 | 44.3 ± 2.4 | 0.07 | 45.7 ± 3.0 | 0.0002 | 0.004 |
| Bicarbonate (mmol/L) | - | 22.7 ± 2.3 | 22.9 ± 2.6 | 0.8 | 25.2 ± 3.0 | <0.0001 | <0.0001 |
| Cac (mg/dl) | 9.3 ± 0.7 | 9.7 ± 0.7 | 9.1 ± 0.5 | <0.0001 | 8.9 ± 0.3 | <0.0001 | 0.02 |
| Hypercalcemia (>10.2 mg/dl) (%) | 9 | 22 | 2 | <0.0001 | 0 | 0.0005 | 0.32 |
| Calcidiol (μg/L) | 33.6 ± 16.7 | 23.6 ± 11.0 | 27.3 ± 14.5 | 0.07 | 29.1 ± 14.3 | <0.05 | 0.42 |
| Sufficient (≥30)/insufficient (10 to 30)/deficient (<10) (%) | 55/41/4 | 24/68/8 | 38/56/6 | 0.32 | 46/46/8 | 0.06 | 0.6 |
| Calcitriol (ng/L) | 21.4 [15.2 to 27.1] | 38.3 [30.9 to 50.0] | 46.8 [35.3 to 57.6] | 0.93 | 41.2 [33.9 to 51.9] | 0.48 | 0.17 |
| Deficiency (<20) (%) | 55 | 10 | 0 | <0.0001 | 8 | 0.72 | 0.60 |
| PTH (ng/L) | 112.5 [66.1 to 233.5] | 35.9 [23.3 to 68.7] | 27.2 [17.0 to 46.0] | 0.008 | 17.5 [11.7 to 24.4] | <0.0001 | 0.003 |
| PTH above K/DOQI targets (%) | 40 | 40 | 32 | 0.06 | 10 | 0.0005 | 0.007 |
| FGF-23 (ng/L) | 2816 [641 to 10,665] | 73 [43 to 111] | 56 [34 to 78] | 0.008 | 47 [34 to 77] | 0.02 | 0.60 |
| FGF-23 >50 ng/L (%) | 100 | 66 | 57 | 0.10 | 45 | 0.04 | 0.57 |
| Total alkaline phosphatases (IU/L) | 200 [160 to 286] | 169 [146 to 211] | 176 [146 to 230] | 0.94 | 183 [155 to 222] | 0.27 | 0.58 |
| Creatinine (mg/dl) | 7.63 ± 2.39 | 1.59 ± 0.35 | 1.41 ± 0.27 | <0.0001 | 1.49 ± 0.43 | 0.12 | 0.40 |
| eGFR ml/min/1.73m2 (Cockroft and Gault) | - | 51.3 ± 13.2 | 56.6 ± 13.7 | 0.01 | 54.4 ± 15.5 | 0.40 | 0.40 |
| eGFR ml/min/1.73m2 (MDRD) | - | 46.5 ± 11.8 | 52.8 ± 11.5 | <0.0001 | 50.8 ± 15.7 | 0.18 | 0.41 |
| K/DOQI stage 2/3 (%) | - | 32/68 | 42/58 | 0.27 | 44/56 | 0.22 | 0.33 |
| CrCl ml/min/1.73m2 | - | 50.2 ± 26.9 | 54.3 ± 21.0 | 0.19 | 50.4 ± 19.3 | 0.55 | 0.23 |
| Phosphaturia (mg/d) | - | 727 [541 to 977] | 872 [570 to 1025] | 0.53 | 790 [570 to 1089] | 0.87 | 0.71 |
| FEphos (%) | - | 45 ± 19 | 37 ± 13 | 0.01 | 35 ± 16 | 0.007 | 0.25 |
| TmP/GFR (mg/dl) | - | 1.52 ± 0.76 | 1.94 ± 1.52 | 0.0006 | 2.18 ± 0.72 | <0.0001 | 0.17 |
Data are represented as mean ± SD or median [interquartile range].
a
CKD, chronic kidney disease; PTH, parathyroid hormone; FGF-23, fibroblast growth factor-23; eGFR, estimated GFR, MDRD, Modification of Diet in Renal Disease; K/DQQI, Kidney Disease Outcomes Quality Initiative; CrCl, creatinine clearance; FEphos, fractional phosphorus excretion; TmP/GFR, tubular maximum reabsorption of phosphorus corrected for GFR; Cac, albumin corrected calcium concentration.