Figure 3.

Reproducibility of glucose-lowering effect with repeated injections of NPH insulin, insulin glargine, and insulin detemir.³⁵ Figure contains prediction intervals illustrating potential day-to-day variability in glycemic response. The probability that a subject with a mean GIR over 24 hours of 1 mg/kg/min would experience an effect of less than half of usual (i.e., <0.5 mg/kg/min) is 16% with NPH insulin, 7% with insulin glargine, and 0.7% with insulin detemir. (Copyright 2006 American Diabetes Association. From Diabetes 2004;53:1614–1620. Reprinted with permission from The American Diabetes Association.)