Figure 4.

Comparison of nocturnal hypoglycemic risk with long-acting insulin analogs (a) glargine and (b) detemir versus NPH insulin.⁵¹ Data were modified from the original published description by using a fixed effect, rather than a random effect, meta-analytic model. Analysis was conducted using Review Manager [RevMan] [Computer program] Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008. (Copyright 2007 Cochrane Collaboration, reproduced with permission. From Horvath K, et al. Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2007;(2):CD005613.)