Table 1.

Percent Control Activity (PCA) Values for Non-cellular, Enzyme-based and SK-BR-3 Cell-based Aromatase Bioassays and IC₅₀ Values for the Non-cellular, Enzyme-based Bioassay for Xanthones 1–12.

	non-cellular bioassay				cell-based bioassay
	PCA		IC50	PCA		cytotoxicity
sample	(20 µg/mL)	SEM	(µM)		SEM	(% survival)	SEM
MeOH extracta	18.9	0.76		24.1a	3.06	65.7	1.23
CHCl3 extracta	29.8	1.97		16.5a	2.39	58.5	1.18
1	57.8	0.47
2	82.6	0.61
3	10.0	0.87	5.2	50.7b	0.78	89.4	1.32
4	23.9	0.50	25.1	32.3b	3.23	52.3	0.73
5	75.9	2.84
6	55.1	0.87
7	52.6	1.06
8	22.2	0.93	20.7	59.4b	3.49	18.4	0.70
9	4.7	1.20	6.9	−0.5b	1.45	30.5	0.54
10	78.8	1.07
11	80.8	1.01
12	74.7	1.62
DMSOc	100.0	0.44		100.0	14.71	100.0	1.19
AGc	15.7c	0.55
Letd				7.4d	1.05

^aMethanol and chloroform extracts of mangosteen (G. mangostana). Extracts were tested at 20 µg/mL in both non-cellular and cell-based assays.

^bCompounds 3, 4, 8, and 9 were tested at 50 µM in the cell-based assay.

^cDimethyl sulfoxide (DMSO), blank/negative control for both noncellular and cell-based bioassay.

^cAminoglutethimide (AG, 50 µM), positive control for non-cellular bioassay.

^dLetrozole (Let, 10 nM), positive control for cell-based bioassay.