Figure 2.

The voltage-dependence of NMDA receptor-mediated currents is a good indicator of NMDA receptor subtype expression.A-C show current responses to NMDA bath applied to the same NK1R+ neuron as in Figure 1. (A) NMDA-evoked current response is the same as in Figure 1. (B) Co-application of NMDA and UBP141, an NR2C/D preferring antagonist, induced a smaller inward current. The I-V relationship shows a more pronounced negative slope conductance. (C) Co-application of NMDA and EAB318, an NR2A/B preferring antagonist, induced NMDA receptor-mediated current with less negative slope conductance.