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Site-directed mutagenesis of the conserved PTP-active site cysteine stops Cpp1p from interfering with the S. cerevisiae pheromone response pathway. Growth of S. cerevisiae cells on selective media with or without pheromone is shown. Cells contain the plasmids pRS314GAL (vector), pGALCPP1-M178 containing the extended region of CPP1 homology with MSG5, or pGALCPP1-M178 with the essential PTP-active site cysteine changed to a serine (pGALCPP1-M178-C516S).
