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A saturating level of MPH (2uM) alone in culture did not alter TH+ neuron survival but it completely attenuated the MDMA induced survival effect. As MPH levels were reduced in increments of 1:10, the MDMA survival effect returned when MPH was reduced to 0.002 μM. This implies that MPH was able to outcompete MDMA at the DAT at higher concentrations and block the survival effect of MDMA at the DAT. (Post-hoc comparisons: *= p<0.05; graphs represent a merging of 3 repeated experiments)
