Table 2.
Systolic blood pressure, postprandial blood glucose level, left kidney weight, renal cortical thiobarbituric acid reactive substances, and mRNA expression of p22phox and gp91phox in LETO and OLETF rats at 11 wk of agea
| LETO | OLETF | OLETF + Olmesartan | OLETF + Temocapril | OLETF + Olmesartan + Temocapril | OLETF + Hydralazine | |
|---|---|---|---|---|---|---|
| SBP (mmHg) | 121 ± 7 | 131 ± 6 | 117 ± 2c | 118 ± 3c | 112 ± 4c | 117 ± 4c |
| PPBG (mmol/L) | 6.6 ± 0.1 | 7.1 ± 0.4 | 6.9 ± 0.3 | 6.7 ± 0.4 | 6.5 ± 0.3 | 6.6 ± 0.2 |
| LKW (g) | 1.12 ± 0.03 | 1.39 ± 0.02b | 1.35 ± 0.02b | 1.35 ± 0.03b | 1.36 ± 0.02b | 1.42 ± 0.04b |
| TBARS (nmol/mg protein) | 0.10 ± 0.02 | 0.22 ± 0.01b | 0.13 ± 0.02c | 0.15 ± 0.01b,c | 0.14 ± 0.02c | 0.20 ± 0.01b |
| p22phox mRNA (fold) | 1.00 ± 0.03 | 2.81 ± 0.19b | 1.38 ± 0.15c | 1.44 ± 0.15c | 1.31 ± 0.14c | 1.98 ± 0.08b |
| gp91phox mRNA (fold) | 1.00 ± 0.14 | 1.30 ± 0.11 | 0.90 ± 0.17 | 1.09 ± 0.16 | 0.82 ± 0.11 | 1.35 ± 0.15 |
a
Values are means ± SEM. SBP, systolic BP; PPBG, postprandial blood glucose level; LKW, left kidney weight; TBARS, thiobarbituric acid reactive substances.
b
P < 0.05 versus LETO.
c
P < 0.05, OLETF versus OLETF + olmesartan, temocapril, olmesartan plus temocapril or hydralazine.