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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Biol Psychiatry. 2008 Mar 28;64(3):192–202. doi: 10.1016/j.biopsych.2008.01.018

Figure 1.

Figure 1

Brain regions involved in the extended reward and oversight system. Prefrontal and cingulate regions connect to the nucleus accumbens (NAc) in the ventral striatum, the midbrain ventral tegmental area (VTA), and reciprocally with other limbic system structures (limbic brainstem, amygdala, and hippocampus). Limbic structures also interconnect with the NAc and to the basal forebrain (substantia innominata, or sublenticular extended amygdala: SLEA). The VTA projects to the NAc (reciprocally), to the thalamus and hypothalamus, and to prefrontal cortex. The NAc projects to the thalamus, which projects to prefrontal cortex.