Table 4.

Partial correlations (Pr) between behavioral data and volumes of subcomponents of the reward circuitry, controlled for effects of Age and Total Cerebrum Volume (only regions with significant Group effects were included in correlation analyses). No significant correlations were observed for IQ or for other drinking history measures.

		Nonalcoholic Comparison Subjects n=20		Subjects with Alcoholism n=21
Region	Test	Pr	p	Pr	p
Total Reward	Length of Sobriety	-	-	0.26	0.3
Total Amygdala	Length of Sobriety	-	-	−0.32	0.2
Total Anterior Insula	Length of Sobriety	-	-	0.60	0.007
Total Dorsolateral Prefrontal Cortex	Length of Sobriety	-	-	0.11	0.7
Total Nucleus Accumbens	Length of Sobriety			0.47	0.04
Total Reward	General Memory	−0.01	0.9	−0.32	0.2
Total Amygdala	General Memory	−0.07	0.8	0.61	0.006
Total Anterior Insula	General Memory	−0.50	0.03	−0.37	0.12
Total Dorsolateral Prefrontal Cortex	General Memory	0.06	0.8	−0.28	0.2
Total Nucleus Accumbens	General Memory	−0.11	0.7	−0.22	0.4
Total Reward	Working Memory	−0.03	0.9	0.57	0.01
Total Amygdala	Working Memory	0.13	0.6	0.21	0.4
Total Anterior Insula	Working Memory	−0.25	0.3	0.27	0.3
Total Dorsolateral Prefrontal Cortex	Working Memory	−0.23	0.4	0.34	0.2
Total Nucleus Accumbens	Working Memory	0.10	0.7	0.06	0.8