Table 3.
Adjusted odds ratio of EGF polymorphism in various subgroups
| Subset Categories | Cases/ Controls |
G/G vs A/A | |
|---|---|---|---|
| Adjusted OR (95% CI)* | P-value | ||
| Lowest of first quartile age of onset (<55.2 years) | 75/111 | 2.04 (0.8-5.3) | 0.14 |
| Second quartile age of onset (55.2-64.5 years) | 87/111 | 2.30 (1.0-5.0) | 0.04 |
| Third quartile age of onset (64.5-72.4 years) | 86/110 | 1.24 (0.6-2.7) | 0.59 |
| Fourth quartile age of onset (>72.4 years) | 59/111 | 1.49 (0.5-4.1) | 0.44 |
| Node-negative cancer (Stages I-IIA) | 94/443 | 2.26 (1.2-4.3) | 0.01 |
| Node-positive cancer (Stages IIB-III) | 157/443 | 1.64 (1.0-2.7) | 0.05 |
| Metastatic cancer (Stage IV) | 82/443 | 1.41 (0.7-2.8) | 0.31 |
| Women | 33/55 | 16.5 (1.5-220) | 0.005 |
| Men | 274/388 | 1.6 (1.0-2.4) | 0.05 |
| Never-smoker | 62/142 | 1.09 (0.5-2.5) | 0.85 |
| Ex-smoker | 168/228 | 2.07 (1.2-3.6) | 0.01 |
| Current smoker | 77/73 | 2.80 (1.1-7.6) | 0.04 |
| Ever smoker, pack-years (0.1-30) | 111/151 | 3.07 (1.5-6.2) | 0.002 |
| Ever smoker, pack-years > 30 | 134/150 | 1.69 (0.9-3.3) | 0.13 |
| Healthy adult BMI < 25 | 212/364 | 2.23 (1.4-3.6) | 0.001 |
| Healthy adult BMI > 25 | 95/79 | 1.00 (0.4-2.3) | 0.94 |
*
adjusted for age, gender, smoking status, pack-years, adult BMI , and the heterozygous variant, A/G; note that in some models, specific variables will not contribute to the model (e.g. smoking status in the never smoking subset of patients)