Figure 1.

Rat Psychomotor Vigilance Task. Response latencies are slowed (Panel A), and the mean number of lapses, including omissions, increased significantly (Panel B) after a 300-μM adenosine (AD) infusion into the basal forebrain (BF), compared with baseline and artificial cerebrospinal fluid (aCSF) controls. These behavior effects are reversed by codialysis of 300 μM of adenosine with 1 μM of 8-cyclopentyltheophyline (CPT, an adenosine A₁ receptor antagonist) in comparison with the 300-μM adenosine-only condition (Panels A & B). The number of premature errors per session decreased after the 300-μM adenosine infusion into the CBF, compared with baseline and aCSF control, but this reduction was reversed after codialysis of 300 μM of adenosine with 1 μM of CPT (Panel C). *P < 0.05, **P < 0.025, ***P < 0.01, ****P < 0.005. Base refers to nondialysis baseline. Error bars ± SEM.