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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Brain Res. 2008 Jul 8;1231:121–131. doi: 10.1016/j.brainres.2008.06.115

Figure 3.

Figure 3

Influence of hypercapnia (lo, hi; pCO2 of 50-55 and 70-75 mm Hg), hypotension (mod, sev; 25 and 45% reductions in mean arterial blood pressure), and isoproterenol (10-8, 10-6 M) (panels A-C) on pial artery diameter. Conditions are before (control), 1h after hypoxia/ischemia (pO2 of 35 mm Hg for 10 min followed by global cerebral ischemia for 20 min) (H/I), 1h after H/I pretreated with IgG (10 μg/ml) 30 min prior to H/I, 1h after H/I pretreated with RAP (10-7 M), 1h after H/I pretreated with anti LRP antibody (anti LRP Ab) (10 μg/ml), and 1h after H/I pretreated with U 0126 (10-6 M), n=6 for all except n=3 for IgG. Baseline small artery diameter for control, H/I, H/I + IgG, H/I + RAP, H/I + anti LRP Ab, and H/I + U 0126 were 144 ± 11, 119 ± 9, 118 ± 8, 138 ± 6, 136 ± 7, and 132 ± 7 μm, respectively. *P<0.05 versus corresponding control value +P<0.05 versus corresponding non pretreated H/I value.