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. 2008 Aug 19;112(9):3671–3678. doi: 10.1182/blood-2008-05-157016

Figure 1.

Figure 1

The expansion FluM1-specific CD8+ T cells in LAIV-vaccinated humanized mice. (A) LAIV vaccine was given intraperitoneally/intravenously; TT vaccine was used as the control. (B) At day 12 after vaccination, the frequency of CD8+ T cells binding FluM1-tetramer and HIVgag-tetramer in the blood was analyzed by flow cytometry. Analysis gates are set for high intensity tetramer staining. Representative data from an experiment with 3 mice vaccinated with LAIV or TT. (C) The frequency of FluM1-specific CD8+ T cells in the blood at day 12 after vaccination from 4 experiments with 4 different donors. Two-tailed nonparametric Mann-Whitney test. (D) The frequency of CD8+ T cells binding FluM1-tetramer and HIVgag-tetramer in the spleen and lungs at day 14 after vaccination. (E) The frequency of FluM1-tetramer+ CD8+ T cells in the blood correlates with their frequency in the spleen (Spearman correlation, P < .001) and (F) in the lung (Spearman correlation, P < .001).