Table 2.

Mean Concentrations E₂, T, or 3α-diol in the Plasma of aged, Intact; Young, Intact; and Young, GDX Male Mice 1 h Following Administration of Vehicle or 1 mg/kg s.c. E₂, T, or 3α-diol, 1 h before Testing

Condition	E2 (pg/mg)	T (ng/mg)	3α-diol (ng/mg)
Aged, intact mice
Vehicle (n = 4)	0.4 ± 0.1	0.4 ± 0.1	0.4 ± 0.1
E2 (n = 4)	2.0 ± 0.3*	0.5 ± 0.2	0.8 ± 0.2
T(n = 4)	1.4 ± 0.3*	2.9 ± 1.7*	1.6 ± 0.2*
3α-diol (n = 4)	0.5 ± 0.2	0.4 ± 0.04	2.5 ± 0.6*
Young, intact mice
Vehicle (n = 5)	7.5 ± 3.0	2.7 ± 1.5	6.4 ± 5.0
E2 (n = 5)	9.3 ± 1.2	1.8 ± 0.8	4.4 ± 2.3
T(n = 5)	2.6 ± 1.7	5.1 ±1.7	2.6 ± 1.5
3α-diol (n = 5)	5.6 ± 1.7	4.2 ±1.5	9.5 ± 3.3
Young. GDX mice
Vehicle (n = 5)	0.8 ± 0.5	0.3 ± 0.4	0.3 ± 0.1
E2(n = 5)	2.0 ± 0.7#	0.4 ± 0.3	0.2 ± 0.1
T(n = 5)	2.8 ± 1.8#	0.3 ± 0.2	0.6 ± 0.1
3α-diol (n = 5)	0.6 ± 0.3	0.3 ± 0.2	0.6 ±0.2

^*Denotes significant difference from vehicle (P < 0.05).

^#denotes tendency to be different from control (P <0.10).