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. Author manuscript; available in PMC: 2008 Oct 27.
Published in final edited form as: Acta Neurochir Suppl. 2008;101:93–98. doi: 10.1007/978-3-211-78205-7_16

Fig. 3.

Fig. 3

High doses of MA altered TUNEL and THir in nigrostriatal pathway. BMPRIIDN (A1) and WT (A2) mice were sacrificed on the 4th day after MA administration (10 mg/kg, ×4). MA injection induced TUNEL labeling. There is an enhancement of TUNEL activity in SNpc (−3.64 mm to bregma) in the BMPRIIDN (A1), compared to the WT (A2). Calibration: 50 μm. (B) The optical density of TUNEL labeling was averaged in 2 regions in SNpc (AP to bregma: −3.64 and −3.80 mm). MA injection significantly increased TUNEL density in the BMPRIIDN mice (p< 0.05, 2-way ANOVA). (C1–C3) THir in nigra and striatum after MA injection in BMPRIIDN and WT mice. THir was examined at 4th day after MA injection. MA significantly reduced THir in striatum and SNpr in the WT mice. There is no difference in THir in striatum and nigra with and without MA treatment in the BMPRIIDN mice (*p<0.05, 1-way ANOVA)